Accelerating the
global companies of tomorrow

SouthUp provides the infrastructure, connections, and know-how that turn a startup into a thriving global company.

Let's talk arrow_forward Our companies grid_view
Our Alumni & Growing Companies
LumenGuides Inretio Bariks Liquid360 Nakai Fungit Biosolutions RumaFeed Growee Biotization BioTip Degem GENIE
Facts and Figures
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Startups grown in the incubator
0
Total capital raised by incubator companies
0
Quality jobs created in the Western Negev
2017
Year the incubator was founded
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Sqm of advanced innovation campus
Our services

A toolkit that turns
a startup into a global company

A hybrid model that gives a company every tool it needs to accelerate — Without enforcing, without dilution.

Strategic guidance & mentoring

Personalized guidance from founders, CEOs, and industry and academic experts in Israel and abroad — from building strategy and a business plan to marketing and go-to-market (GTM) moves.

Funding & financial support

Full support with the Israel Innovation Authority and regional acceleration programs. Access to an increased grant of up to 72% of R&D expenses in the early stages.

Investment & fundraising

Connections to investors and venture capital funds, plus focused guidance to build the foundation for raising capital.

Advanced innovation campus

3,000 sq.m of offices, labs, and advanced work infrastructure across two sites — at Kibbutz Nir Am and in the Sha'ar HaNegev Regional Council area.

Human capital & a supportive ecosystem

Connection to the community and support in recruiting top talent in the Western Negev, building strong teams from a growing, dynamic ecosystem.

Connections that create growth

Direct access to industry, strategic partners, and experienced mentors. Working sessions, pilots, and collaborations.

explore From Tel Aviv to the incubator — one hour
train
Tel AvivTrain station
SouthUp · Sha'ar HaNegevNext to the Sderot train station
From the field

What do theentrepreneurs say?

And what do our entrepreneurs say?

Raviv Vine
”
The value of SouthUp goes far beyond providing office space. We received a complete support that every early-stage startup needs – connections to hospitals in the region, access to high-quality talent, professional guidance, and services that helped us move forward much faster. Looking back, choosing SouthUp was one of the best decisions we made. After two years, we faced the dilemma of whether to relocate to central Israel to be closer to the medical ecosystem. In the end, we realized that this is our home. We decided to stay in the region, and today we operate from the "Sapirin" Industrial Part at Sha'ar HaNegev.
Raviv VineCEO of Inretio
Dr. Liat Avrahami-Moyal
”
Very quickly, we realized that southern Israel was the natural place for us, thanks to its agricultural ecosystem, high-quality workforce, and regional incentives. After completing the incubator program, we chose to continue our growth at SouthUp. We required unique infrastructure for development and manufacturing, and the incubator provided us with a fast, professional, and precise response to our needs. Throughout the entire journey, we benefited from collaboration, a positive attitude, and a genuine willingness to help. That support enabled us to focus on what truly matters – developing our technology and growing our company.
Dr. Liat Avrahami-MoyalFounder and CTO of Fungit Biosolutions
Pninit Gilboa-Tal
”
We were looking for a home that would offer us much more than office space – a place that would support us throughout our journey. At SouthUp, we found an exceptional team whose entire mission is to help start-ups succeed. They connect us with investors, industry experts, and the right partners, allowing us to focus on what truly matters – developing our company and our technology.
Pninit Gilboa-TalFounder and CEO of Biotization
100%
Support

Infrastructure, Ecosystem, Expertise — A Tailored Support Envelope for Every Company's Stage of Growth

0%
Equity

Period.

100%
Guidance & acceleration

Connections that create real growth.

72%
Increased grant from the Innovation Authority A 20% grant bonus for National Priority Area A development approval on top of the Innovation Authority's base grant
Our companies

75 Companies

swipe Categories — scroll sideways to choose

MedTech

LumenGuide

An advanced, radiation-free autonomous navigation system for lung procedures.

CEO: Limor Frigan
MedTech

YOPI

A wearable device that measures electrolyte changes in sweat — a physiological snapshot of heart and lung function.

CEO: Hemi Ram
MedTech

Inretio

An innovative approach to blood-clot retrieval and stroke treatment.

CEO: Raviv Vine
DefenceTech

Liquid360

A comprehensive intelligence and vision system for rapid, tactical, real-time response.

CEO: Alisia Gibrats
DefenceTech

Robel · Asgard

Project management and implementation solutions in defense and aviation.

CEO: Rotem Mital
DefenceTech

Nakai

Project management solutions in defense and aviation.

CEO: Rotem Mital
AgriTech

Fungit Biosolutions

Microorganism-based biological solutions for crop protection and prevention of fungal diseases.

CEO: Yoav Shkolnik
AgriTech

RumaFeed

Molecular technology that halts toxin production in potato foliage and turns the waste into protein-rich hay.

CEO: Oded Ilan
AgriTech

Groweecv

A smart hydroponic system for real-time monitoring and control of water, fertilizers, and environmental conditions.

CEO: Idan Avitan
DeepTech

Degem

Advanced 3D-printing technology for industrial serial production.

CEO: Maor Abergil
DeepTech

GENIE

A tool for real-time identification, treatment, and monitoring of mental and neurological conditions.

CEO: Dr. Sharon Daniel
AI

OtefAI

Developing AI technologies for integration into development tools and DevOps.

CEO: Gal Kimron
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Our programs

A complete defense ecosystem for acceleration

A DefenceTech ecosystem combining land, air, and sea testing environments, a direct line to the DDR&D (MAFAT) at the Ministry of Defense, and acceleration programs in defense, HLS, and dual-use solutions. The incubator scouts promising technologies and startups, runs feasibility studies, provides a professional support framework, and connects them to defense bodies, industry, and relevant customers. The ecosystem also includes the HLS.IL community — a platform for connections, collaborations, and market access with thousands of members.

Go to program page arrow_forward

Agricultural innovation – from field to lab

A unique agricultural ecosystem linking R&D, entrepreneurship, and needs from the field, in partnership with Sapir Academic College (the HAI Center at Sapir), the NES Foundation, and the Western Negev Cluster of Authorities. Activity focuses on four main tracks: R&D and innovation, acceleration of entrepreneurs and companies, professional training, and guiding and implementing new technologies among farmers in Sha'ar HaNegev and the Western Negev. The model connects academic knowledge, technology, and farmers – advancing solutions from the lab to the field.

Advanced medicine & digital health

Accelerating MedTech companies through a support framework that includes access to labs, connections with hospitals and research institutes, and unique funding programs. We guide companies from the prototype stage through regulatory approval processes, and help bridge the world of research to the global health market.

Deep tech & artificial intelligence

A dedicated program for DeepTech and AI companies developing breakthrough technologies – from the lab to the market. The program provides access to advanced computing infrastructure, collaborations with academia and industry, professional expertise, and a network of investors specializing in these fields. The framework helps companies tackle development challenges, shorten the path from proof of concept to commercialization, and accelerate the move from innovative technology to product and market.

SouthUp in the media

SouthUp in the media

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    mail Keren@southup.org location_on Sha'ar HaNegev Regional Council · D.N. Hof Ashkelon, 78100 call 08-9459704